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Title:
MEDICAL USE OF COMBINATION OF SELECTIVE ESTROGEN RECEPTOR MODULATOR WITH SEX STEROID PRECURSOR
Document Type and Number:
Japanese Patent JP2007191484
Kind Code:
A
Abstract:

To provide a medical treatment of osteoporosis, breast cancer, hypercholesterolemia, hyperlipemia or atherosclerosis in a warm-blooded animal including a human being, and/or a novel method for preventing progress thereof.

This method comprises administering a selective estrogen receptor modulator, particularly having a structure of general formula (I) (wherein R1, R2are each a hydroxy group or the like; and n=2 or the like), and a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3β, 17β-diol and compounds converted in vivo to any of these compounds, and further administering a bisphosphonate and a selective estrogen receptor modulator and/or a sex steroid precursor. A pharmaceutical composition and a kit are also provided.

COPYRIGHT: (C)2007,JPO&INPIT


Inventors:
LABRIE FERNAND
Application Number:
JP2007054169A
Publication Date:
August 02, 2007
Filing Date:
March 05, 2007
Export Citation:
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Assignee:
ENDORECH INC
International Classes:
A61K31/5685; A61K31/133; C07D333/56; A61K31/381; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/4436; A61K31/4453; A61K31/453; A61K31/475; A61K31/56; A61K31/565; A61K31/568; A61K31/57; A61K31/66; A61K31/663; A61K45/00; A61K45/06; A61P3/06; A61P9/10; A61P15/00; A61P15/02; A61P19/10; A61P21/00; A61P35/00; A61P43/00; C07D209/10; C07D311/60
Foreign References:
WO1996026201A11996-08-29
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani