Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
【発明の名称】医薬組成物
Document Type and Number:
Japanese Patent JP2543690
Kind Code:
B2
Abstract:
The use is claimed of N-phenyl-N'-phenalkyl- (2-5C) alkylenediamines of formula R1-NR2-A-NR3-B-R4 (I, certain of which are new, or their pharmaceutically acceptable salts or solvates, for the prepn. of a medicament for the treatment or prophylaxis of angina where R1, R4 = phenyl opt. substd. by 1-3 of halogen, CF3, 1-4C alkyl, 1-4C alkoxy, CN, OH, NO2, NR5R6 or SO2NR5R6, or disubstd. on adjacent C atoms by 1-2C alkylenedioxy and opt. further substd. by one of the above gps. R5,R6 = H or 1-6C alkyl or together are 3-6C polymethylene, R2 = (CH2)zCN, 1-12C alkyl, 3-7C cycloalkyl, 3-7C cycloalkyl- (1-4C)alkyl, phenyl-(1-4C)alkyl, pyridyl, pyridyl-(1-4C)alkyl, COR7, COCH2COR7, SO2R7, CO2R7, CONHR7 or CSNHR7, any pyridyl or phenyl gp. in R2 opt. being substd. as for R1 and R4 and any cycloaklyl gp. in R2 opt. being substd. by 1 or 2 (1-4C)alkyl gps. R7 = 3-12C alkyl, 3-7C cycloalkyl, 3-7C cycloalkyl-(1-4C)alkyl, phenyl or phenyl-(1-4C) alkyl, any alkyl gp. being opt. substd. by OH or 1-4C alkanoyloxy; R3 = H or 1-4C alkyl; A = 2-5C alkylene; and B = 1-4C alkylene. (I) are new provided that (R1,R2,A,R3,B,R4) are not the following combinations: (3,4-dimethoxyphenyl, Et, (CH2)2, H, (CH2)2, phenyl), (3,4-dimethoxyphenyl, Et, (CH2)2, H, CH2, phenyl), (Ph, COnPr, (CH2)2, Me, CH2,Ph), (Ph,COiPr, (CH2)2, Me, CH2, Ph), (Ph, COnPr, CH(Me)CH2, Me,(CH2)2,Ph) (PH,ConPr (Ph,COnBu,CH2CHMe,Me,(CH2)2,Ph), (Ph,PhCH2,(CH2)2, H,(CH2)2,Ph), (Ph,PhCH2,(CH2)2,Me,CH2,Ph), (Ph,PhCH2.(CH2)2,Me,(CH2)2,Ph), (Ph,PhCH2,(CH2)2,Me,(CH2)3,Ph), (4-Cl-Ph, PhCH2,(CH2)2, H,(CH2)2,Ph), (4-Cl-Ph,PhCH2,(CH2)2, Me,(CH2)2,Ph), (Ph,4-Cl-PhCH2-, (CH2)2,Me,(CH2)2,Ph), (Ph,PhCH2,(CH2)2,4-Cl-Ph).

Inventors:
HARARUDO MASHURAA
Application Number:
JP3133087A
Publication Date:
October 16, 1996
Filing Date:
February 13, 1987
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
BIICHAMU UERUFUINGU GMBH UNTO CO KG
International Classes:
A61K31/36; A61K31/135; A61K31/16; A61K31/165; A61K31/17; A61K31/18; A61K31/195; A61K31/205; A61K31/22; A61K31/27; A61K31/275; A61K31/357; A61K31/44; A61P3/00; A61P9/00; A61P9/06; A61P9/08; A61P9/10; C07C67/00; C07C209/00; C07C209/10; C07C209/50; C07C211/48; C07C213/00; C07C217/84; C07C231/00; C07C231/12; C07C233/00; C07C233/25; C07C233/36; C07C233/37; C07C233/62; C07C233/66; C07C233/83; C07C235/10; C07C235/26; C07C235/80; C07C237/00; C07C237/10; C07C239/00; C07C253/00; C07C255/24; C07C255/58; C07C255/60; C07C261/04; C07C269/00; C07C275/34; C07C275/40; C07C301/00; C07C311/02; C07C311/15; C07C311/18; C07C325/00; C07C335/04; C07D213/74; C07D317/62; C07D317/66; (IPC1-7): C07C233/78; A61K31/165; C07C231/02; C07C253/30; C07C255/24
Other References:
【文献】米国特許4268439(US,A)
【文献】米国特許3528990(US,A)
【文献】米国特許3365453(US,A)
【文献】英国特許1050132(GB,A)
Attorney, Agent or Firm:
Masamitsu Akizawa (1 person outside)