MEDICINE COMPOSITION FOR MEDICAL TREATMENT OF DISEASE RELATED TO NA ION NON-DEPENDENT CL ION/CARBONIC ACID HYDROGEN ION EXCHANGER

Title:

MEDICINE COMPOSITION FOR MEDICAL TREATMENT OF DISEASE RELATED TO NA ION NON-DEPENDENT CL ION/CARBONIC ACID HYDROGEN ION EXCHANGER

Document Type and Number:

Japanese Patent JPH08301754

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To obtain the subject pharmaceutical composition by including a benzopyran derivative. SOLUTION: This composition contains, as active ingredient, a compound of the formula ((n) is 0 or 1; R1 to R4 are each H or an alkyl; R5 is H, an alkyl, alkylcarbonyl, etc.; R6 is H, an alkyl, phenyl, etc.; R7 to R9 are each a halogen, alkyl, etc.; R10 and R11 are each H, an alkyl, etc.), e.g. N-(2,4,6- trimethylphenyl)-(6-acetoxy-3,4-dihydro-2,5,7,8-tetramethyl-2H(1)-benz opyran-2-yl) carboxamide. This composition is useful for preventing/treating gastrointestinal diseases (e.g. gastric ulcer, duodenal ulcer), bone diseases (e.g. osteoporosis, arthritis), diseases associated with central nervous system and cerebral edema ischemic or traumatic origin, renal diseases (e.g. diabetic nephropathy), cardiovascular diseases (e.g. ischemia, stenocardia, arrhythmia), pancreatic fibrosis, pulmonary diseases, diabetes, cytotoxicity due to anticancer agents, Alzheimer's disease, etc., its daily dose being 0.1 mg to 1 g.

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Inventors:

RIYUDOBUISU DEYURAN
JIYANNPOORU BABINGI
KUROODEI MURAN
SHIRUBII ROBEERUUPIESAARU
GIYOOMU RU BOOTO
ERIZABESU SUKARUBEERU
DANIERUUANRI KANIYAARU
PIEERU RENAARU

Application Number:

JP11157296A

Publication Date:

November 19, 1996

Filing Date:

May 02, 1996

Export Citation:

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Assignee:

ADIR

International Classes:

C07D311/58; A61K31/35; A61K31/352; A61K31/353; A61P1/00; A61P1/04; A61P3/08; A61P3/10; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P19/10; A61P25/28; A61P43/00; C07D311/70; C07D311/72; (IPC1-7): A61K31/35; A61K31/35; C07D311/70; C07D311/72

Attorney, Agent or Firm:

Hajime Tsukuni (2 outside)

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