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Title:
MEDICINE CONTAINING HETEROARYL-SUBSTITUTED PYRROLE DERIVATIVE
Document Type and Number:
Japanese Patent JP2002284779
Kind Code:
A
Abstract:

To obtain a compound capable of controlling production of inflammatory cytokine.

This compound is represented by general formula (I) {A is a pyrrole ring; R1 is a substitutable aryl or a substitutable heteroaryl; R2 is a substitutable heteroaryl; R3 is a group of general formula X-R4 [X is a single bond, a substitutable alkylene, a substitutable alkenylene or a substitutable alkynylene; R4 is a substituted cycloalkyl, a substituted aryl group, a substituted heterocyclyl, a substitutable heteroaryl group or NRaRb (Ra and Rb are each H, an alkyl, an alkenyl, an alkynyl, an aralkyl, an alkylsulfonyl)] with the proviso that atoms on the pyrrole ring to which R1 and R3 are bonded are adjacent to an atom on the pyrrole ring to which R2 is bonded, respectively} or its pharmacologically acceptable salt, ester or other derivative.


Inventors:
KIMURA TOMIO
AOKI KAZUMA
NAKAO AKIRA
USHIYAMA SHIGERU
SHIMOZATO RYUICHI
OKAWA NOBUYUKI
Application Number:
JP2002000007128
Publication Date:
October 03, 2002
Filing Date:
January 16, 2002
Export Citation:
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Assignee:
SANKYO CO
International Classes:
C07D401/04; A61K31/437; A61K31/4375; A61K31/439; A61K31/4439; A61K31/4545; A61K31/46; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D401/14; C07D451/02; C07D453/02; C07D455/02; C07D471/04; (IPC1-7): C07D401/04; A61K31/437; A61K31/4375; A61K31/439; A61K31/4439; A61K31/4545; A61K31/46; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D401/14; C07D451/02; C07D453/02; C07D455/02; C07D471/04
Attorney, Agent or Firm:
大野 彰夫 (外4名)