Title:
トリフルオロメチル基含有アルコール類の製造方法
Document Type and Number:
Japanese Patent JP6763747
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing trifluoromethyl group-containing alcohols useful as synthetic intermediates for medicines and agrochemicals.SOLUTION: This invention relates to a method for producing trifluoromethyl group-containing alcohols expressed by a formula (2), comprising: making carbonyl compounds expressed by a formula (1) react with trifluoromethane in an organic solvent in the presence of polyvalent ethers and potassium tert-butoxide, or kalium hexamethyldisilazide. (Rand Rare each independently a phenyl group etc.; Rmay combine with R, to form a ring, and both R1 and R2 are not hydrogen atoms).SELECTED DRAWING: None
Inventors:
Tetsuo Shibata
Takuya Saito
Takumi Kagawa
Takuya Saito
Takumi Kagawa
Application Number:
JP2016212014A
Publication Date:
September 30, 2020
Filing Date:
October 28, 2016
Export Citation:
Assignee:
National Institute of Technology Nagoya Institute of Technology
Tosoh Finechem Co., Ltd.
Tosoh Finechem Co., Ltd.
International Classes:
C07C29/38; C07B41/02; C07C33/46; C07C33/48; C07C35/52; C07C41/30; C07C43/23; C07C201/12; C07C205/26; C07C213/00; C07C215/68; C07D213/30; C07D307/42; C07D311/84; C07D333/16
Domestic Patent References:
| JP2014519486A |
Other References:
品田英泰et al.,トリフルオロメタンを用いた含フッ素有機化合物の合成研究,日本大学生産工学部学術講演会講演概要,2013年,46th, ROMBUN No.4-32
PRAKASH, G. K. Surya et al.,Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers,Science,2012年,vol.338,pp.1324-1327
RUSSELL Jamie et al.,Effective Nucleophilic Trifluoromethylation with Fluoroform and Common Base.,Tetrahederon,1998年,54,pp.13771-13782
PRAKASH, G. K. Surya et al.,Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers,Science,2012年,vol.338,pp.1324-1327
RUSSELL Jamie et al.,Effective Nucleophilic Trifluoromethylation with Fluoroform and Common Base.,Tetrahederon,1998年,54,pp.13771-13782
Attorney, Agent or Firm:
Norio Hagi