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Title:
METHOD OF APPLYING ETFB TO ABNORMAL PROLIFERATION OF CELLS, AND ABNORMAL PROLIFERATION INHIBITOR
Document Type and Number:
Japanese Patent JP2016116537
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide means for distinguishing the abnormal proliferation of a fibroblasts at an early stage and inhibiting the same.SOLUTION: The invention provides a method for distinguishing the state of the proliferation of a fibroblast, which employs the degree of expression of an electron transfer flavoprotein beta subunit (ETFB) as a measure, in which it is determined that the probability of occurrence of abnormal proliferation of the fibroblast is high when the degree of the expression of the ETFB is high, and it is determined that the probability of maintenance in a normal state of the proliferation of the fibroblast is high when the degree of the expression of the ETFB is low. The abnormal proliferation of a fibroblast can be prevented by inhibiting an ETFB.SELECTED DRAWING: Figure 4

Inventors:
HIROKAWA SHIGENARI
KITAJIMA HIROYUKI
SHIMANUKI TOMOMASA
Application Number:
JP2016064443A
Publication Date:
June 30, 2016
Filing Date:
March 28, 2016
Export Citation:
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Assignee:
POLA PHARMA INC
International Classes:
C12Q1/68
Foreign References:
Other References:
HIROKAWA S. ET AL.,, JOURNAL OF DERMATOLOGICAL SCIENCE, 22 AUGUST, 2011, VOL.64, PP.119-126, JPN6012011208
"Journal of Investigative Dermatology", 2007, VOL.127, PP.526-537, JPN6015048952
"Experimental and Molecular Pathology", 2010, VOL.89, PP.236-240, JPN6015048954
"Homo sapiens full open reading frame cDNA clone RZPDo834G0315D for gene ETFB, electron-t", ACCESSION NO. CR456827, CR456827.1, [ONLINE], NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, 2008年1, JPN6012011211
Attorney, Agent or Firm:
川口 嘉之
佐貫 伸一
丹羽 武司
下田 俊明