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Title:
METHOD AND COMPOSITION FOR TREATING SECONDARY TISSUE DAMAGE AND OTHER INFLAMMATORY CONDITION AND DISORDER
Document Type and Number:
Japanese Patent JP2010075194
Kind Code:
A
Abstract:

To provide a method for treating an inflammation response associated with activation, proliferation and migration of immune effector cells, including leukocyte cell types, neutrophils, macrophages and eosinophils, by using conjugates containing a chemokine receptor targeting agent such as chemokine as a ligand and a targeted agent like a toxin.

The conjugates are used to target toxins to receptors on secondary tissue damage-inducing cells. The ligand moiety can be selected to deliver the cell toxin to such secondary tissue damage-inducing cells as mononuclear phagocytes, leukocytes, natural killer cells, dendritic cells, and T and B lymphocytes, thereby suppressing the proliferation, migration, or physiological activity of such cells. Among preferred conjugates are fusion proteins having a chemokine, or a biologically active fragment thereof, as the ligand moiety linked to a cell toxin via a peptide linker of from 2 to about 60 amino acid residues.


Inventors:
MCDONALD JOHN R
COGGINS PHILIP J
Application Number:
JP2009264178A
Publication Date:
April 08, 2010
Filing Date:
November 19, 2009
Export Citation:
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Assignee:
OSPREY PHARMACEUTICALS USA INC
International Classes:
C12N15/00; C12N15/09; A61K31/711; A61K38/00; A61K39/395; A61K47/48; A61K48/00; A61P1/04; A61P5/14; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P13/12; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07K14/415; C07K14/47; C07K14/52; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/19; C12N15/29; C12N15/31; C12P21/02
Domestic Patent References:
JP2001514502A2001-09-11
JPH08502075A1996-03-05
JPH08511765A1996-12-10
Foreign References:
WO1995012414A11995-05-11
WO2000004926A22000-02-03
Other References:
JPN6012042914; ONCOLOGY REPORTS, 1996年, vol. 3, p. 175-179
JPN7012003393; Cytokine, 1997年, vol. 9, no. 8, p. 587-596
JPN6012042907; J. Immunol., 1989年, vol. 143, no. 11, p. 3498-3502
JPN7012003394; Proc. Natl. Acad. Sci. USA, 1988年, vol. 85, no. 11, p. 3980-3984
JPN7012003395; NATO ASI Ser. A, 1992年, vol. 238, p. 19-29
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto