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Title:
METHOD AND INTERMEDIATE FOR PRODUCING ANTICANCER COMPOUND
Document Type and Number:
Japanese Patent JP3420549
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To obtain an anticancer compound in a high yield useful for treating a highly proliferative disorder such as cancer in mammals by using a specific synthetic intermediate.
SOLUTION: (A) A compound of formula I [R1 and R2 are each a 1-10C alkyl, a 1-10C alkoxy, preferably R1 and R2 are each 2-methoxyethoxy; R15 is H, a 1-10C alkyl or the like, preferably H; G is C(OH)R3R4 or SiR3R4R5 (R3 to R5 are each a 1-6C alkyl)] is treated, (B) in the case of G being C(OH)R3 R4, with an alkaline (earth) metal hydroxide in a hydroxy-substituted 1-10C alkyl-containing solvent or, (C) in the case of G being SiR3R4R5, with a tetra (1-6C alkyl)ammonium fluoride compound in an aprotic solvent to give a compound of formula II. The compound of formula I can be obtained by treating a compound of formula III with a compound of formula IV.


Inventors:
Lehner, Richard Shelton
Norris, Timothy
Santafianos, Dinos Paul
Application Number:
JP2000000091300
Publication Date:
June 23, 2003
Filing Date:
March 29, 2000
Export Citation:
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Assignee:
PFIZER PROD INC
International Classes:
C07D239/94; A01N43/54; A61K31/00; A61K31/33; A61K31/40; A61K31/498; A61K31/505; A61K31/517; A61P35/00; C07B61/00; C07D235/14; C07D239/70; C07D239/72; C07D239/74; C07D239/95; C07D401/00; C07D403/00; C07D405/00; C07D409/00; C07D413/00; C07D417/00; C07D419/04; C07D455/02; C07D471/04; C07D473/00; C07D475/00; C07D491/048; C07F7/08; C07F7/10; C22B3/04; C22B15/00; A61K; C07D; (IPC1-7): C07D239/94
Attorney, Agent or Firm:
社本 一夫 (外5名)



 
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