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Title:
METHOD FOR PREPARING PHOSPHOROTHIOATE OLIGOMER
Document Type and Number:
Japanese Patent JP2001192395
Kind Code:
A
Abstract:

To obtain an oligonucleotide having largely excessive diastereomers and containing an optically isomerically pure phosphorothioate bond, a phosphorus-bonded oligonucleotide containing substantially whole Rp bonds or whole Sp bonds, a research material and a diagnostic material for examining a physical state of animal, especially a disease state and a sequence-specific oligonucleotide containing am optically isomerically pure phosphorothioate bond and to provide a method for synthesizing an intermediate useful for the synthesis of the oligonucleotide.

This method synthesizes a phosphorothioate bond oligonucleotide rich in diastereomers. This intermediate is useful for the synthesis. This method chemically synthesizes a sequence-specific phosphorothioate oligonucleotide containing a chiral phosphorus bond and other oligonucleotides.


Inventors:
JUST GEORGE
XIN ZHILI
MARSAULT ERIC
JIN YI
WANG JIANCHAO
Application Number:
JP2000361189A
Publication Date:
July 17, 2001
Filing Date:
October 18, 1996
Export Citation:
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Assignee:
UNIV MCGILL
International Classes:
C07H21/04; B01J31/02; C07F9/141; C07F9/6584; C07H9/04; C07H9/06; C07H19/10; C07H21/00; C12N15/09; C12Q1/68; (IPC1-7): C07H21/04; C07F9/6584
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)