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Title:
METHOD FOR PRODUCING 4-(2-METHYL-1-IMIDAZOLYL)-2,2-DIPHENYLBUTANE AMIDE
Document Type and Number:
Japanese Patent JP2010013485
Kind Code:
A
Abstract:

To provide a method for producing an incontinence-treating agent, 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutane amide (KRP-197) industrially by improving the operability of the production process and its yield, increasing its purity and reducing a harmful solvent or the like.

The industrial scale method for producing the agent KRP-197 at high purity by simple operations and in high yield is provided by isolating 4-(2-methyl-1-imidazolyl)-2,2- diphenylbutyronitrile which is an intermediate for the production, as a phosphoric acid salt or its hydrate, hydrolyzing it in the presence of an alkali metal hydroxide, and then purifying the resulting substance by using a synthetic adsorbent.


Inventors:
IWAI YASUMASA
AMADA JUNICHIRO
AIZAWA YASUHIRO
ONODA MICHIRO
Application Number:
JP2009000242125
Publication Date:
January 21, 2010
Filing Date:
October 21, 2009
Export Citation:
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Assignee:
KYORIN SEIYAKU KK
International Classes:
C07D233/61
Foreign References:
WO1995015951A11995-06-15
Attorney, Agent or Firm:
箕浦 清



 
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