METHOD FOR PRODUCING CELL HIGHLY SENSITIVE TO STRESS USING NUCLEIC ACID

Title:

METHOD FOR PRODUCING CELL HIGHLY SENSITIVE TO STRESS USING NUCLEIC ACID

Document Type and Number:

Japanese Patent JP2015027290

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide means for making a cultured cell highly sensitive to environmental stress comprehensively, without using an RNA interference method with problems such as adverse effects, and without individually measuring the presence of specific chemical material for example in a reporter assaying method, to increase sensitivity of an environmental stress evaluating method in which a cultured cell of mammals and the like is used.SOLUTION: The present invention comprises highly expressing GAS5, and/or IDI2-AS1 and SNHG15, which are RNA molecules having the same function as GAS5, in a cultured cell of mammals and the like, so that the cultured cell becomes highly sensitive to environmental stress such as chemical material and ultraviolet rays.

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Inventors:

TANI HIDENORI
TORIMURA MASAMOTO

Application Number:

JP2014125587A

Publication Date:

February 12, 2015

Filing Date:

June 18, 2014

Export Citation:

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Assignee:

NAT INST OF ADV IND & TECHNOL

International Classes:

C12N5/10; C12M1/34; C12N15/09; C12Q1/02; C12Q1/68

Other References:

ONCOGENE, vol. (2009)Vol.28, p195-208, JPN6018008528
GENOME RES., vol. (2012), Vol.22, p947-956, JPN6018008534
BIOCHEM.BIOPHYS.RES.COMMUN., vol. (2013)VOl.439,p547-551, JPN6018008536
GENE.THER.MOL.VIOL., vol. (2006) Vol.10(B), p255-262, JPN6018008532

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