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Title:
METHOD FOR PRODUCTION OF CLARITHROMYCIN
Document Type and Number:
Japanese Patent JP2005015459
Kind Code:
A
Abstract:

To provide a practical, efficient method for synthesizing 6-O-methyl-erythromycin A from an erythromycin A 9-oxime derivative or its hydrochloride salt as a starting material.

This 6-O-methyl-erythromycin A is a compound derived from erythromycin A 9-O-aryl oxime containing two structures represented by the formula. In the structures, one of the group A, B or C is at least one nitrogen atom; one of the group X, Y or Z is at least one unit of an erythromycin A oxime derivative; R1 and R2 are simultaneously hydrogen or -Si(CH3)3; R3 is -N(CH3)2; and R4 is hydrogen or -CH3.


Inventors:
BRUNET ROMERO ERNESTO
RODRIGUEZ URBIS JUAN CARLOS
CRUZADO RODRIGUEZ MARIA DEL CA
ASENSIO DOMINGUEZ RAMON
Application Number:
JP2003000345011
Publication Date:
January 20, 2005
Filing Date:
August 28, 2003
Export Citation:
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Assignee:
ERCROS IND SA
International Classes:
C07H17/08; C07F7/18; (IPC1-7): C07H17/08; C07F7/18
Attorney, Agent or Firm:
中平 治