To provide a method for suppressing abdominal pain by regulating a T-type calcium channel, an abdominal pain inhibitor containing a T-type calcium channel inhibitor as an active ingredient, and a method for screening an abdominal pain inhibitor by investigating a T-type calcium channel inhibitor activity.
There are provided the method for suppressing abdominal pain comprising activating a function of alpha 1G T-type calcium channel to suppress abdominal pain in a central nervous system and suppressing functions of alpha 1H and alpha 1I T-type calcium channels to suppress abdominal pain in a peripheral nervous system, the abdominal pain inhibitor containing a T-type calcium channel inhibitor as an active ingredient, and the method for screening an abdominal pain inhibitor by investigating a T-type calcium channel inhibitor activity. In the method for suppressing abdominal pain by regulating a T-type calcium channel, abdominal pain can be suppressed by a precise mechanism and regulated without side effect.
COPYRIGHT: (C)2007,JPO&INPIT
KIM DAE-SOO
KIM CHAN-KI
WO1999028342A2 | 1999-06-10 | |||
WO1995004028A1 | 1995-02-09 |