To provide a synthetic reaction capable of forming a covalent bond between a carbon atom in an organic compound and an oxygen atom or a nitrogen atom of another organic compound easily under mild reaction conditions.

In the presence of a diazo compound, a coupler compound having a leaving group other than a hydrogen atom is made to react with a nucleophilic compound. Concretely, for example, in the presence of a compound of formula D-11, a compound of formula C-7 is made to react with a compound of formula N-26 to manufacture a compound of formula S-9.