To provide a method for forming a 7 membered oxathiazepine ring in high yield by controlling a three-dimensional structure.
This method for synthesizing an oxathiazepine ring is to synthesize a compound having an oxathiazepine ring expressed by general formula B by using a methyl thiomethyl ether compound expressed by general formula A. (In formulae A and B, R1 and R2 express each a straight chain which may have substituents, a branched or cyclic alkyl, an aralkyl, a ring made of those and having an N atoms as a ring member or a 5 membered or 6 membered ring condensed with the aforesaid ring having the N atom as the ring member or a group or an atomic group constituting a condensed ring having those several rings; R3 expresses H, OH or the like; R4 expresses an alkyl or the like or may form an acetal structure with other lower alcohol; when R3 is OH or an alkoxycarbonylamino, R3 can form an intramolecular acetal structure with R4; R5 is the same as R3).
TOKUYAMA HIDETOSHI
YAMASHITA TORU