Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHODS FOR T CELL REGULATION
Document Type and Number:
Japanese Patent JP2017206550
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for screening therapeutic agents and medicines for treating immune response disorders in patients having malignant tumor, as with a variety of diseases characterized by development of progressive immunosuppression in the patients.SOLUTION: Although regulatory T cells limit autoimmunity, they may also attenuate the level of anti-pathogen and antitumor immunity. It is necessary to identify Treg-specific receptors for understanding of the mechanism of Treg function and in vivo therapeutic treatment of Treg. The comparative analysis of gene expression arrays from antigen specific CD4+T cells that differentiate to either an effector/memory or a regulatory phenotype revealed Treg-specific expression of LAG-3(CD223), a CD4 homologue that binds to MHC class II.SELECTED DRAWING: None

Inventors:
PARDOLL DREW M
HUANG CHING TAI
VIGNALI DARIO A
WORKMAN CREG J
POWELL JONATHAN
DRAKE CHARLES C
Application Number:
JP2017142742A
Publication Date:
November 24, 2017
Filing Date:
July 24, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV JOHNS HOPKINS
ST JUDE CHILDRENS RES HOSPITAL INC
International Classes:
A61K35/17; A01N43/04; A61K31/70; A61K31/7088; A61K31/7105; A61K31/713; A61K39/00; A61K39/38; A61K39/395; A61K45/00; A61K48/00; A61P11/06; A61P25/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07K14/705; C07K16/00; C07K16/28; C07K19/00; C12N5/0783; C12P21/08; C12Q1/02; G01N33/53; A61K35/12; C12N
Domestic Patent References:
JP2000508226A2000-07-04
JP2002505582A2002-02-19
Foreign References:
Other References:
EUR. J. IMMUNOL., 1996, VOL.26, P.1180-1186, JPN6015005051, ISSN: 0004176373
EUR. J. IMMUNOL., 2002, VOL.32, P.2255-2263, JPN6015005053, ISSN: 0004176374
CURRENT OPINION IN IMMUNOLOGY, 2002, VOL.14, PP.771-778, JPN6016024925, ISSN: 0004176375
Attorney, Agent or Firm:
Shimizu Hatsushi
Koichi Niimi