Title:
フラビウィルス科ウィルス感染治療用の修飾2′および3′-ヌクレオシドプロドラッグ
Document Type and Number:
Japanese Patent JP2005533817
Kind Code:
A
Abstract:
2' and/or 3' prodrugs of 1', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
Inventors:
Somadosi, Jiyan-Pierre
La Cotura, Paolo
Strawr, Lichyard
Goslan, Jill
La Cotura, Paolo
Strawr, Lichyard
Goslan, Jill
Application Number:
JP2004517158A
Publication Date:
November 10, 2005
Filing Date:
June 27, 2003
Export Citation:
Assignee:
Idenix (Cayman) Limited
Unibercita Detsuri Stoday Day Cagliari
Center Nacional Dou la Lucier Ciuyan Xanteihuik
Unibercita Detsuri Stoday Day Cagliari
Center Nacional Dou la Lucier Ciuyan Xanteihuik
International Classes:
C07H19/06; A61K9/20; A61K9/48; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K38/00; A61K38/21; A61K45/00; A61P31/14; A61P43/00; C07H19/00; C07H19/04; C07H19/044; C07H19/048; C07H19/052; C07H19/056; C07H19/067; C07H19/10; C07H19/12; C07H19/14; C07H19/16; C07H19/167; C07H19/20; C07H19/22; C07H19/23; (IPC1-7): C07H19/06; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K45/00; A61P31/14; C07H19/16
Domestic Patent References:
| JP2004532184A | 2004-10-21 | |||
| JP2005530759A | 2005-10-13 | |||
| JP2005527499A | 2005-09-15 |
Foreign References:
| WO2001092282A2 | 2001-12-06 | |||
| WO2001090121A2 | 2001-11-29 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura