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Patent Searching and Data


Title:
MODIFIED NUCLEOTIDE
Document Type and Number:
Japanese Patent JPH11292892
Kind Code:
A
Abstract:

To obtain a new oligo- or polynucleotide which is chemically modified or labeled in such a manner that it is easily detected when it is bound to or taken into a nucleic acid substance, and as a result, which is useful for diagnosing carcinoma or the like, by containing a nucleotide having a specific structure.

The subject nucleotide contains a nucleotide of the formula (P is a phosphoric acid residue; S is a deoxyribose residue; B is pyrimidine, purine or the like; when said nucleotide is a ribonucleotide, P binds to a position selected from 2'-, 3'- and 5'-positions of S, when it is a deoxyribonucleotide, P binds to a position selected from 3'and 5'-positions of S, and when B is a pyrimidine, the N1 position binds to the 1-position of S, and when B is purine, the N9 position binds to the 1'-position of S; Sig is a detectable residue which is bound to S directly or via a bonding group). The nucleotide of the formula is obtained by adding a nucleic acid to an allyl amine substituent with a covalent bond, and subsequently binding a heavy metal or the like.


Inventors:
ENGELHARDT DEAN
RABBANI ELAZAR
KLINE STANLEY
STAVRIANOPOULOS JANNIS G
KIRTIKAR DOLLIE
Application Number:
JP841599A
Publication Date:
October 26, 1999
Filing Date:
January 14, 1999
Export Citation:
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Assignee:
ENZO BIOCHEM INC
International Classes:
A61K47/48; C07B59/00; C07H19/04; C07H19/10; C07H19/20; C07H21/02; C12N9/00; C07H21/04; C07K17/06; C08B37/00; C12N15/00; C12N15/09; C12Q1/68; C12Q1/70; G01N33/50; G01N33/53; G01N33/566; G01N33/58; (IPC1-7): C07H21/02; C07H21/04; G01N33/50; G01N33/58
Attorney, Agent or Firm:
Akira Asamura (1 person outside)