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Title:
MULTICHAIN POLYPEPTIDE OR PROTEIN
Document Type and Number:
Japanese Patent JPH1080296
Kind Code:
A
Abstract:

To obtain the subject new polypeptide comprising Ig fragment or molecule produced from recombinant DNA technique in a single host cell, containing a variable domain of IgH chain and L chain and having immunological function and useful as a composition, etc., for medical treatment, etc.

This polypeptide is a new Ig fragemnt or Ig molecule produced by recombinant DNA technique in a single host cell, comprising at least a variable domain of immunoglobulin (Ig)H chain and L chain and having immunological function and useful as an active ingredient, etc., of composition for treatment. The polypeptide or protein is obtained by separating DNA code sequence of functional fragment of Ig molecule comprising a variable domain of H chain and L chain having desired specificity from a cell producing hybridoma Ig, inserting the sequence into a plasmid together with DNA code sequence of unchangeable domain of Ig molecule, transforming the host by using the built plasmid and expressing individual chain in the transformed host cell and treating the chain.


Inventors:
BOSS MICHAEL A
KENTEN JOHN H
EMTAGE JOHN S
WOOD CLIVE R
Application Number:
JP1997000104862
Publication Date:
March 31, 1998
Filing Date:
April 22, 1997
Export Citation:
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Assignee:
CELLTECH LTD
International Classes:
G01N33/577; A61K38/00; A61K39/00; A61K39/395; A61K47/00; A61P7/00; B01D15/08; C07H1/00; C07H21/04; C07K14/00; C07K16/00; C07K16/18; C07K16/46; C07K19/00; C12N1/15; C12N1/18; C12N1/19; C12N1/20; C12N1/21; C12N5/10; C12N15/00; C12N15/09; C12N15/13; C12N15/63; C12P21/00; C12P21/02; C12P21/08; G01N33/531; C12R1/125; C12R1/19; C12R1/865; (IPC1-7): C12P21/02; A61K38/00; A61K39/395; C07H21/04; C07K16/00; C12N15/09; C12P21/08
Attorney, Agent or Firm:
浅村 皓 (外1名)