Title:
【発明の名称】シクロオキシゲナーゼ及び5-リポキシゲナーゼを阻害するN(3-ビフェニリル-1(s)-メチル-2-プロペニル)アセトヒドロキサム酸誘導体
Document Type and Number:
Japanese Patent JPH08509718
Kind Code:
A
Abstract:
The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or cyclooxygenase mediated arachidonic acid metabolic pathway is indicated. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention. In formula (I), X is cyano, fluoro, or chloro; or a salt, solvate, or physiologically functional derivative thereof.
Inventors:
Hodgson, Simon Teenby
Weights, Peter John
Weights, Peter John
Application Number:
JP52401994A
Publication Date:
October 15, 1996
Filing Date:
April 26, 1994
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/275; A61P1/00; A61P1/04; A61P11/00; A61P43/00; C07C17/263; C07C33/28; C07C33/48; C07C45/00; C07C45/72; C07C49/235; C07C239/10; A61K31/165; C07C239/18; C07C255/53; C07C255/56; C07C255/60; C07C259/06; C07C271/00; C07C271/08; C07C275/64; (IPC1-7): C07C259/06; A61K31/165; A61K31/275; C07C33/48; C07C49/235; C07C239/10; C07C239/18; C07C255/53; C07C255/56; C07C255/60; C07C271/08
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)