Title:
NOVEL IMIDAZO[1,2-a]PYRIDINE AND IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE
Document Type and Number:
Japanese Patent JP2014196316
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound inhibiting Btk which is a kind of tyrosine kinase and shown to be an important regulator for initial B cell development, mature B cell activation and survival, and useful for rheumatoid arthritis, inflammatory and/or autoimmune diseases, and to provide a pharmaceutical composition containing the compound.SOLUTION: There are provided an imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivative or a pharmaceutical composition containing the compound. (X), where Z is carbon or nitrogen, Ris H, -R, -R-R-R, -R-Ror -R-R, Ris aryl, heteroaryl, cycloalkyl and the like, Ris -C(=O), -C(=O)O, -C(=O)NH and the like, Ris H or R, Ris lower alkyl, lower alkoxy, aryl, arylalkyl, alkylaryl, heteroaryl, alkylheteroaryl, heteroarylalkyl and the like.
Inventors:
NOLAN JAMES DEWDNEY
LOU YAN
SOTH MICHAEL
LOU YAN
SOTH MICHAEL
Application Number:
JP2014116005A
Publication Date:
October 16, 2014
Filing Date:
June 04, 2014
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/496; A61K31/5025; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/695; A61P19/06; A61P29/00; A61P37/06; A61P43/00; C07D487/04; C07D519/00; C07F7/10
Domestic Patent References:
| JP5643105B2 | 2014-12-17 | |||
| JP2006507254A | 2006-03-02 | |||
| JP5643105B2 | 2014-12-17 |
Foreign References:
| WO2006100119A1 | 2006-09-28 | |||
| WO2006053121A2 | 2006-05-18 | |||
| WO2006100119A1 | 2006-09-28 | |||
| WO2006053121A2 | 2006-05-18 |
Other References:
JPN7012005033; ＹＡＭＡＭＯＴＯ，Ｎ． ｅｔ ａｌ: 'Ｔｈｅ ｏｒａｌｌｙ ａｖａｉｌａｂｌｅ ｓｐｌｅｅｎ ｔｙｒｏｓｉｎｅ ｋｉｎａｓｅ ｉｎｈｉｂｉｔｏｒ ２-［７-（３，４-ｄｉｍｅｔｈｏｘｙｐｈｅｎｙｌ）-ｉｍｉｄａｚｏ［１，２-ｃ］ｐｙｒｉｍ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｖｏｌ．３０６， Ｎｏ．３, 2003, ｐ．１１７４-１１８１
JPN7012005033; ＹＡＭＡＭＯＴＯ，Ｎ． ｅｔ ａｌ: 'Ｔｈｅ ｏｒａｌｌｙ ａｖａｉｌａｂｌｅ ｓｐｌｅｅｎ ｔｙｒｏｓｉｎｅ ｋｉｎａｓｅ ｉｎｈｉｂｉｔｏｒ ２-［７-（３，４-ｄｉｍｅｔｈｏｘｙｐｈｅｎｙｌ）-ｉｍｉｄａｚｏ［１，２-ｃ］ｐｙｒｉｍ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｖｏｌ．３０６， Ｎｏ．３, 2003, ｐ．１１７４-１１８１
JPN7012005033; ＹＡＭＡＭＯＴＯ，Ｎ． ｅｔ ａｌ: 'Ｔｈｅ ｏｒａｌｌｙ ａｖａｉｌａｂｌｅ ｓｐｌｅｅｎ ｔｙｒｏｓｉｎｅ ｋｉｎａｓｅ ｉｎｈｉｂｉｔｏｒ ２-［７-（３，４-ｄｉｍｅｔｈｏｘｙｐｈｅｎｙｌ）-ｉｍｉｄａｚｏ［１，２-ｃ］ｐｙｒｉｍ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｖｏｌ．３０６， Ｎｏ．３, 2003, ｐ．１１７４-１１８１
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Ito 佐保子
Toshio Miyake
Akio Shibata
Yasuhiro Kokuni
Yoko Tanaka
Yoshinori Ubukawa
Hajime Tsukuni
Yasuo Yanagibashi
Ito 佐保子
Toshio Miyake
Akio Shibata
Yasuhiro Kokuni
Yoko Tanaka
Yoshinori Ubukawa
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