Title:
新規バイオ開裂性リンカー
Document Type and Number:
Japanese Patent JP2008510795
Kind Code:
A
Abstract:
The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula 1.
Inventors:
Apparao SATYAM
Application Number:
JP2007529100A
Publication Date:
April 10, 2008
Filing Date:
August 26, 2005
Export Citation:
Assignee:
Apparao SATYAM
NICHOLAS PIRAMAL INDIA LIMITED
NICHOLAS PIRAMAL INDIA LIMITED
International Classes:
C07C323/12; A61K31/167; A61K31/195; A61K31/216; A61K31/23; A61K31/325; A61K31/337; A61K31/4015; A61K31/405; A61K31/415; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/422; A61K31/435; A61K31/4422; A61K31/4523; A61K31/455; A61K31/4709; A61K31/495; A61K31/50; A61K31/53; A61K31/5513; A61K31/57; A61K31/616; A61K31/7072; A61K47/20; A61K47/22; A61K47/48; A61P3/02; A61P5/30; A61P9/12; A61P25/00; A61P25/08; A61P29/00; A61P35/00; A61P37/00; C07C323/25; C07C323/43; C07C323/52; C07D207/27; C07D207/46; C07D211/90; C07D213/80; C07D213/82; C07D231/10; C07D233/88; C07D235/04; C07D237/20; C07D261/08; C07D295/08; C07D309/10; C07D401/04; C07D401/12; C07D403/10; C07D405/12; C07D413/12; C07D495/04; C07H19/073; A61P31/04
Domestic Patent References:
| JP2005510574A | 2005-04-21 | |||
| JPH10504022A | 1998-04-14 | |||
| JP2002522443A | 2002-07-23 | |||
| JP2000511197A | 2000-08-29 | |||
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| JP2001520670A | 2001-10-30 | |||
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| JPH02111731A | 1990-04-24 |
Foreign References:
| WO2003014072A1 | 2003-02-20 | |||
| WO2003040104A1 | 2003-05-15 | |||
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| WO2004069159A2 | 2004-08-19 | |||
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Other References:
JPN6011033594; ＭＩＣＨＡＥＬ，Ｋ． ｅｔ ａｌ: 'Ｅｎｈａｎｃｅｄ ＲＮＡ ｂｉｎｄｉｎｇ ｏｆ ｄｉｍｅｒｉｚｅｄ ａｍｉｎｏ ｇｌｙｃｏｓｉｄｅｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７， Ｎｏ．７, 1999, ｐ．１３６１-１３７１
JPN6011033595; ＡＮＮＡＥＲＴ，Ｐ． ｅｔ ａｌ: 'Ｃｏｍｐａｒｉｓｏｎ ｏｆ ｔｈｅ ｄｉｓｐｏｓｉｔｉｏｎ ｏｆ ｅｓｔｅｒ ｐｒｏｄｒｕｇｓ ｏｆ ｔｈｅ ａｎｔｉｖｉｒａｌ ａｇｅｎｔ ９-（２-ｐｈｏｓｐｈｏｎｙｌｍｅｔｈｏｘｙｅｔｈｙｌ）ａ' Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１５， Ｎｏ．２, 1998, ｐ．２３９-２４５
JPN6011033596; ＰＯＳＮＥＲ，Ｇ．Ｈ． ｅｔ ａｌ: 'Ｔｒｉｏｘａｎｅ ｄｉｍｅｒｓ ｈａｖｅ ｐｏｔｅｎｔ ａｎｔｉｍａｌａｒｉａｌ， ａｎｔｉｐｒｏｌｉｆｅｒａｔｉｖｅ ａｎｄ ａｎｔｉｔｕｍｏｒ ａｃｔｉｖｉｔｉｅｓ ｉｎ ｖｉｔｒｏ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５， Ｎｏ．７, 1997, ｐ．１２５７-１２６５
JPN6011033597; ＧＩＲＡＲＤＥＴ，Ｊ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｎｔｉｔｕｍｏｒ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｓｏｍｅ ｎｅｕｔｒａｌ ｔｒｉｅｓｔｅｒｓ ｏｆ ５-ｆｌｕｏｒｏ-２'-ｄｅｏｘｙｕｒｉｄｉｎｅ ５'-ｍｏｎｏｐｈｏｓ' Ｎｕｃｌｅｏｓｉｄｅｓ ＆ Ｎｕｃｌｅｏｔｉｄｅｓ Ｖｏｌ．１４， Ｎｏ．３-５, 1995, ｐ．６４５-７
JPN5003023556; ＩＣＨＩＫＡＷＡ， Ｍ．: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１１ Ｎ１３, 2001, Ｐ１７６９-１７７３
JPN6011033595; ＡＮＮＡＥＲＴ，Ｐ． ｅｔ ａｌ: 'Ｃｏｍｐａｒｉｓｏｎ ｏｆ ｔｈｅ ｄｉｓｐｏｓｉｔｉｏｎ ｏｆ ｅｓｔｅｒ ｐｒｏｄｒｕｇｓ ｏｆ ｔｈｅ ａｎｔｉｖｉｒａｌ ａｇｅｎｔ ９-（２-ｐｈｏｓｐｈｏｎｙｌｍｅｔｈｏｘｙｅｔｈｙｌ）ａ' Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１５， Ｎｏ．２, 1998, ｐ．２３９-２４５
JPN6011033596; ＰＯＳＮＥＲ，Ｇ．Ｈ． ｅｔ ａｌ: 'Ｔｒｉｏｘａｎｅ ｄｉｍｅｒｓ ｈａｖｅ ｐｏｔｅｎｔ ａｎｔｉｍａｌａｒｉａｌ， ａｎｔｉｐｒｏｌｉｆｅｒａｔｉｖｅ ａｎｄ ａｎｔｉｔｕｍｏｒ ａｃｔｉｖｉｔｉｅｓ ｉｎ ｖｉｔｒｏ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５， Ｎｏ．７, 1997, ｐ．１２５７-１２６５
JPN6011033597; ＧＩＲＡＲＤＥＴ，Ｊ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｎｔｉｔｕｍｏｒ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｓｏｍｅ ｎｅｕｔｒａｌ ｔｒｉｅｓｔｅｒｓ ｏｆ ５-ｆｌｕｏｒｏ-２'-ｄｅｏｘｙｕｒｉｄｉｎｅ ５'-ｍｏｎｏｐｈｏｓ' Ｎｕｃｌｅｏｓｉｄｅｓ ＆ Ｎｕｃｌｅｏｔｉｄｅｓ Ｖｏｌ．１４， Ｎｏ．３-５, 1995, ｐ．６４５-７
JPN5003023556; ＩＣＨＩＫＡＷＡ， Ｍ．: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１１ Ｎ１３, 2001, Ｐ１７６９-１７７３
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita