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Title:
NEW COMPOUND AND ITS USAGE AS MEDICAL DRUG
Document Type and Number:
Japanese Patent JPH05148202
Kind Code:
A
Abstract:

PURPOSE: To provide a new compound useful as a IV-type allergy-inhibitory medicine.

CONSTITUTION: Compounds of formula I [X1 is formula II or III (R1-R4 are H, amino, an acylamino, a 1-5C dialkylamino, a halogen, OH, etc.); (m1) is 1-6; (n1) is 0-5], e.g. 1-(4-hydroxy-3-methoxycinnamoyl)-4-methylpiperidine-4- carboxylic acid. The compound of formula I is obtained, e.g. by reacting 4- acetoxy-3-methoxycinnamoyl chloride with 4-piperidinecarboxylic acid at room temperature. IV-type allergic reaction takes part in crisis of intractable diseases such as intractable ashtma, chronic hepatitis and nephrotic syndrome.


Inventors:
EDA SHOEI
WARATANI KOJI
ONO YUTAKA
OZAWA HIDEYUKI
KAWAMURA HIDEKI
CHIN MASAO
WAKAMATSU TAKESHI
Application Number:
JP1992000075678
Publication Date:
June 15, 1993
Filing Date:
February 27, 1992
Export Citation:
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Assignee:
TSUMURA & CO
International Classes:
A61K31/12; A61K31/16; A61K31/165; A61K31/19; A61K31/215; A61K31/357; A61K31/36; A61K31/415; A61K31/4184; A61K31/4427; A61K31/443; A61K31/445; A61K31/4468; A61K31/454; A61P37/08; C07C62/04; C07C62/20; C07C62/24; C07C62/30; C07C62/34; C07C62/36; C07C62/38; C07C69/734; C07C233/09; C07C233/40; C07C233/78; C07C235/34; C07C235/36; C07C235/54; C07C237/20; C07C237/22; C07C271/22; C07C323/25; C07D211/16; C07D211/58; C07D211/62; C07D233/54; C07D233/60; C07D233/70; C07D233/88; C07D235/06; C07D295/092; C07D295/185; C07D295/22; C07D309/12; C07D317/60; C07D401/12; C07D405/12; C07D407/12; C07D493/08; C07D521/00; (IPC1-7): A61K31/12; A61K31/16; A61K31/165; A61K31/19; A61K31/215; A61K31/36; A61K31/415; A61K31/445; C07C233/09; C07C233/40; C07C235/34; C07C237/20; C07C237/22; C07D211/16; C07D211/62; C07D233/60; C07D233/70; C07D233/88; C07D235/06; C07D295/22; C07D317/60; C07D401/12; C07D405/12; C07D407/12