To produce a new erythromycin, having excellent antimicrobial activities against Gram-positive bacteria, etc., and useful for treatment, etc., of sensitive microbisms by reacting erythromycins with an N-halo-N-(phenylsulfonyl) benzenesulfonamide.
This new erythromycin is represented by formula I [X is (NH)a [(a) is 0 or 1], CH2, SO2 or O; Y is represented by the formula (CH2)m-(CH= CH)n-(CH2)o {[(m) + (n) + (o)]≤8; (n) is o or 1}; Ar is a (substituted)aryl; Hal is a halogen; Z is H or an acid residue], has excellent antibiotic substance activities against Gram-positive bacteria such as the genus Staphylococcus, Streptococcus or Pneumococcus and is effective in treatment, etc., of sensitive microbism, especially sepsis, pyoderma, acute angina, scarlatina, pneumonia, etc. The compound is obtained by reacting erythromycins represented by formula II with an N-halo-N-(phenylsulfonyl)benzenesulfonamide represented by formula III.
FURANSOWA BURUTAN
JIYANFURANSOWA SHIYANTO
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