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Title:
NEW GLYCYRRHETINIC ACID DERIVATIVE AND SWEETENER
Document Type and Number:
Japanese Patent JPH1028548
Kind Code:
A
Abstract:

To obtain a new glycyrrhetinic acid derivative, having a structure with a sweetness quality and a string sweetness similar to that of sugar and useful for a low-caloric sweetener substitutive for the sugar.

This new glycyrrhetinic acid derivative is a 3β-O-glycyrrhetinic acid ester of L-aspartic acid represented by formula I or a 3β-O-glycyrrhetinic acid ester of L-aspartyl dipeptide represented by formula II (X is glyciner of L-phenylalanine) and a salt thereof and the bond between the L-Asp and the 3β-O of the glycyrrhetinic acid and the bond between the L-Asp and the Z are α- or β-bonds. The derivative can be obtained by a method for condensing glycyrrhetinic acid having the carboy group protected as a benzyl ester with aspartic acid having the amino group protected with t-butoxycarbonyl group and one of carboxyl groups protected with benzyl group, and the removing the protecting groups according to the catalyst reduction and hydrolysis with an acid, etc.


Inventors:
MACHINAMI TOMOYA
SUAMI TETSUO
Application Number:
JP1996000189039
Publication Date:
February 03, 1998
Filing Date:
July 18, 1996
Export Citation:
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Assignee:
AJINOMOTO KK
International Classes:
A23L27/30; C07C229/08; C07C229/36; C07J61/00; C07J63/00; C07K5/072; (IPC1-7): A23L1/236; C07C229/08; C07C229/36; C07J61/00; C07J63/00; C07K5/072