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Title:
NEW HUMAN TISSUE PLASMINOGEN ACTIVATOR MUTANT
Document Type and Number:
Japanese Patent JPH06277071
Kind Code:
A
Abstract:

PURPOSE: To obtain a DNA encoding a new human mutant tissue plasminogen activator.

CONSTITUTION: This DNA encodes a human mutant tissue plasminogen activator which contains an amino acid at the position 275 replaced with an amino acid except arginine by site specific mutation and/or an amino acid at the position 277 replaced with an amino acid except lysine and is produced by a recombinant host cell.


Inventors:
HEYNEKER HERBERT LOUIS (US)
VEHAR GORDON ALLEN (US)
Application Number:
JP1938294A
Publication Date:
October 04, 1994
Filing Date:
February 16, 1994
Export Citation:
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Assignee:
GENENTECH INC
International Classes:
A61K35/12; A61K35/74; A61K38/46; A61P7/02; C12N1/20; C12N1/21; C12N5/00; C12N5/10; C12N9/00; C12N9/64; C12N9/72; C12N15/00; C12N15/09; C12N15/10; C12N15/58; C12N15/67; C12N15/70; C12N15/71; C12P21/00; C12P21/02; C12Q1/00; A61K38/00; C12R1/19; C12R1/91; C12N; (IPC1-7): C12N15/58; C12N1/21; C12N5/10
Domestic Patent References:
JPS5993093A1984-05-29
JPS5942321A1984-03-08
Attorney, Agent or Firm:
青山 葆 (外1名)