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Title:
NEW PARTICLE, ITS PRODUCTION AND USE
Document Type and Number:
Japanese Patent JPH11269097
Kind Code:
A
Abstract:

To obtain particles having excellent biodegradability, capable of having multifunctions and useful as a carrier for medicines by including a block copolymer comprising a specific hydrophobic segment and a specific hydrophilic segment as a base material.

The particles contains a block copolymer having a biodegradable polymer as a hydrophobic segment and a polyamino acid as a hydrophilic segment as a base material. The block copolymer is preferably a polymer of the formula: X-B-Y {X is H, R-CO [R is a (substituted) hydrocarbon or the like], A (A is a polyamino acid residue) or the like; Y is OH, OR2 (R2 is the same as R1), A or the like; B is a group obtained by removing H from the terminal hydroxyl group of the biodegradable polymer and OH from the terminal carboxyl group}, and the particles are preferably nano-sized particles, especially preferably polymer micelles having an average particle diameter of about 10-200 nm.


Inventors:
YAMAMOTO KAZUMICHI
HATA YOSHIO
IGARI YASUTAKA
Application Number:
JP1034299A
Publication Date:
October 05, 1999
Filing Date:
January 19, 1999
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K9/14; A61K47/30; B82B1/00; (IPC1-7): A61K47/30; A61K9/14
Attorney, Agent or Firm:
Tadao Asahina (1 person outside)