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Title:
NEW PYRIMIDINEAMIDE DERIVATIVE AND USE THEREOF
Document Type and Number:
Japanese Patent JP2010043113
Kind Code:
A
Abstract:

To provide use for treatment of diseases corresponding to inhibition of protein kinase activity, especially, treatment of tumor diseases, and a method for treating the diseases.

A new substituted N-(3-benzoylaminophenyl)-4-pyridyl-2-pyrimidineamine derivative is an inhibitor excellent in protein kinase activity, and especially expresses inhibition for one or more Bcr-Ab1, variant Bcr-Ab1, c-Ab1, Raf, receptor tyrosine kinase PDGF-R and the like, and inhibition for two or more of them. Such type of a kinase can be used for treating diseases particularly associated with abnormal or excessive activity, e.g., treatment of leukemia and solid tumors.


Inventors:
MANLEY PAUL WILLIAM
BREITENSTEIN WERNER
JACOB SANDRA
FURET PASCAL
Application Number:
JP2009235252A
Publication Date:
February 25, 2010
Filing Date:
October 09, 2009
Export Citation:
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Assignee:
NOVARTIS AG
International Classes:
C07D401/04; A61K31/496; A61K31/506; A61K31/5377; A61P3/10; A61P7/02; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P17/06; A61P27/02; A61P35/00; A61P35/02; A61P43/00; C07D401/14
Domestic Patent References:
JP4463685B22010-05-19
Foreign References:
WO2002022597A12002-03-21
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Yasushi Ochiai