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Patent Searching and Data


Title:
NEW THIOCARBAMIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH10251224
Kind Code:
A
Abstract:

To obtain the subject new compound useful as an agent for alleviating hypercholesterolemia or an agent for hyperlipemia.

This compound is shown by formula I [R is trifluoromethyl, phenyl, etc.; R1 is H or a lower alkyl; (1) is 0 or 1; X and Z are each carbonyl, etc.; (m) is 0 or 1; (n) is 1 or 2; Y is O, S, etc.; Q is ethylene, trimethylene, etc.; R2 is H or a lower alkyl; A is a group of formula II (R3 and R4 are each H, a halogen, etc.)] such as N-(3-thienyl)-N-methyl-3-(3-aminophenoxy) propylamine. The compound is obtained by reacting a halogenated thioformate of formula III (V is a halogen) with an amine of formula IV in an equimolar amounts or in a little excessive amount of either of the compounds in the presence or absence of a base (sodium hydroxide) in a solventless state or in a solvent (methanol) at -80 to 100°C for several minutes to 24 hours.


Inventors:
TOKUNAGA TAKUMI
TOKUHISA KENJI
ITO HIROYUKI
YAMAMOTO TAKASHI
KATSUURA KIMIO
ISHIDA NAOMICHI
AIDA MASAKI
MATSUNO SUMIO
INOUE YOSHIHISA
YAMAUCHI KENJI
Application Number:
JP35658897A
Publication Date:
September 22, 1998
Filing Date:
December 25, 1997
Export Citation:
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Assignee:
TOSOH CORP
GREEN CROSS CORP
International Classes:
C07D239/26; A61K31/165; A61K31/215; A61K31/275; A61K31/38; A61K31/381; A61K31/41; A61K31/42; A61K31/425; A61K31/426; A61K31/433; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4433; A61K31/505; A61K31/695; A61P3/06; A61P9/10; A61P43/00; C07C333/02; C07C333/08; C07D209/08; C07D209/34; C07D209/44; C07D209/46; C07D213/74; C07D277/20; C07D277/28; C07D277/42; C07D285/08; C07D285/10; C07D333/16; C07D333/20; C07D333/28; C07D333/32; C07D333/36; C07D333/38; C07D409/12; C07D417/12; (IPC1-7): C07C333/02; A61K31/165; A61K31/215; A61K31/275; A61K31/38; A61K31/41; A61K31/42; A61K31/425; A61K31/44; A61K31/505; A61K31/695; C07C333/08; C07D209/08; C07D209/34; C07D209/44; C07D209/46; C07D213/74; C07D239/26; C07D277/28; C07D277/42; C07D285/08; C07D285/10; C07D333/16; C07D333/20; C07D333/28; C07D333/32; C07D333/36; C07D333/38; C07D409/12; C07D417/12
Attorney, Agent or Firm:
Masayuki Kishida (2 outside)