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Title:
NEW THIOL PROTEASE INHIBITOR AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH07252245
Kind Code:
A
Abstract:

PURPOSE: To obtain new substances having inhibiting action on thiol protease participated in inflammation, metastasis, tissue damage after cardiac infarction, muscular dystrophy, etc.

CONSTITUTION: These new inhibitors are PF1138A substance (R=H) and PF1138B substance (R=OH) of the formula (R is H or OH). These substances are obtained by carrying out shake culture, etc., of a PF1138A substance- producing bacterium and/or a PF1138B substance-producing bacterium belonging to the genus Chaetomium in a medium containing a carbon source such as glucose, a nitrogen source such as soybean powder and as necessary, inorganic salts such as sodium, preferably by deep culturing method, preferably at 20-30°C (especially about 25°C), usually for 2-7 days.


Inventors:
TABATA YUJI
ISHII SHIGETAKA
MIIKE NAOKO
YAGUCHI TAKASHI
SOMEYA FUMIKO
HATSU MASAHIRO
IMAI SATOSHI
SHIBAHARA MASAYUKI
Application Number:
JP1994000043639
Publication Date:
October 03, 1995
Filing Date:
March 15, 1994
Export Citation:
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Assignee:
MEIJI SEIKA KAISHA
International Classes:
C12P17/02; A61K31/335; A61K31/336; A61P29/00; A61P35/00; A61P43/00; C07D303/48; C12R1/645; (IPC1-7): C07D303/48; C12P17/02
Attorney, Agent or Firm:
湯本 宏