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Title:
NITROSOUREA DERIVATIVE* ITS MANUFACTURE* DRUG COMPOSITION CONTAINING IT AND UREA DERIVATIVE FOR SAID MANUFACTURE
Document Type and Number:
Japanese Patent JPS5657762
Kind Code:
A
Abstract:
N-nitrosourea derivatives having the formula: wherein X and Y are the same or different, and are selected from the group consisting of a phenyl group and a cyclohexyl group, said phenyl and cyclohexyl groups being optionally substituted with one or two substituents selected from a halogen atom, a lower alkyl group having from one to four carbon atoms inclusive, a trifluoro methyl group, a cyano group, a phenyl group, a cyclohexyl group and a lower alkyloxy group having from one to four carbon atoms inclusive. "Alkylene" is an alkylene group, branched or unbranched, having from one to four carbon atoms inclusive, and R<1> and R<2> are the same or different, and are each selected from the group consisting of lower alkyl groups having from one to four carbon atoms inclusive and benzyl groups, or they form together with the nitrogen atom a saturated five- or sixmembered heterocyclic ring, as well as pharmaceutically acceptable acid addition salts thereof. These compounds are prepared by nitrosating the corresponding urea, which are disclosed. They show antineoplastic effectiveness and can be used in pharmaceutical compositions.

Inventors:
PEETAA BUREGUNEDAARU
IYORUN RATSUSE MAATEIN BUUSU
Application Number:
JP13782580A
Publication Date:
May 20, 1981
Filing Date:
October 03, 1980
Export Citation:
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Assignee:
KEFALAS AS
International Classes:
A61K31/275; A61K31/40; A61P35/00; C07C67/00; C07C239/00; C07C275/68; A61K31/17; (IPC1-7): A61K31/17; A61K31/275; A61K31/40; A61K31/445; C07C135/00; C07D295/12