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Title:
NOVEL AND EFFECTIVE TERMINAL DIFFERENTIATION INDUCER AND METHOD OF USING THE SAME
Document Type and Number:
Japanese Patent JP2008069158
Kind Code:
A
Abstract:

To provide an effective terminal differentiation inducer comprising a pharmacologically acceptable carrier and a therapeutically acceptable amount of the compound described below, and a method of using the same.

The novel and active terminal differentiation inducer is a compound comprising a structure represented by structure (I). A method for inhibiting the growth of tumor cells by selectively inducing the terminal differentiation thereof is disclosed. Further, a therapeutic method for treating a patient having a tumor characterized by the growth of tumorous cells is disclosed.


Inventors:
BRESLOW RONALD
MARKS PAUL A
RIFKIND RICHARD A
JURSIC BRANKO
Application Number:
JP2007242963A
Publication Date:
March 27, 2008
Filing Date:
September 19, 2007
Export Citation:
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Assignee:
SLOAN KETTERING INST CANCER
UNIV COLUMBIA
International Classes:
C07C239/18; A61K31/16; C07D295/18; A61K31/164; A61K31/165; A61K31/167; A61K31/192; A61K31/196; A61K31/197; A61K31/20; A61K31/216; A61K31/221; A61K31/275; A61K31/277; A61K31/425; A61K31/426; A61K31/427; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/52; A61P35/00; A61P35/02; A61P43/00; C07C229/24; C07C229/30; C07C233/05; C07C233/06; C07C233/07; C07C233/15; C07C233/25; C07C233/34; C07C233/36; C07C233/43; C07C233/54; C07C233/64; C07C233/92; C07C237/04; C07C237/42; C07C239/14; C07C255/19; C07C255/42; C07C255/44; C07C255/60; C07C259/06; C07C259/08; C07C259/10; C07C271/10; C07C271/28; C07C275/28; C07D211/16; C07D211/26; C07D211/32; C07D213/56; C07D213/75; C07D277/02; C07D277/20; C07D277/44; C07D277/46; C07D295/185; C07D487/04; C07D519/00
Domestic Patent References:
JPH07502494A1995-03-16
JP2003226680A2003-08-12
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Ryo Hashimoto
Tetsuya Kazama