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Patent Searching and Data


Title:
NOVEL ISOTHIOUREA DERIVATIVE AND PREPARATION THEREOF
Document Type and Number:
Japanese Patent JPS60184062
Kind Code:
A
Abstract:

NEW MATERIAL:A compound of formula I (R is hydrocarbon group).

USE: A synthetic intermediate for novel pyrimidine derivatives.

PREPARATION: A tertiary amine adduct of an octafluoroisobutyl lower alkyl ether of 1-lower alkoxyperfluoroisobuten is reacted with an S-hydrocarbon-substituted isothiourea or an acid salt thereof to give the aimed compound of formula I . The above-mentioned reaction is carried out in the presence of an aprotic polar solvent, e.g. DMF or DMA. The compound of formula I is cyclized in the presence of a catalyst, e.g. a tertiary amine, in an aprotic polar solvent to afford a novel pyrimidine derivative of formula II useful as an antitumor agent. etc.


Inventors:
INOUE YOSHIO
IWA RIICHI
Application Number:
JP4004284A
Publication Date:
September 19, 1985
Filing Date:
March 02, 1984
Export Citation:
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Assignee:
NIPPON MEKTRON KK
International Classes:
C07C335/38; C07C67/00; C07C325/00; (IPC1-7): C07C157/14
Attorney, Agent or Firm:
Toshio Yoshida