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Title:
NOVEL MANUFACTURE OF 1 ALPHA*3 BETAADIHYDROXYYDELTA55STEROID
Document Type and Number:
Japanese Patent JPS5572200
Kind Code:
A
Abstract:
A process for the synthesis of 1 alpha ,3 beta -dihydroxy- DELTA 5-steroids from steroids such as 1 alpha ,2 alpha -epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton donator, said additions being followed in each case by an equivalent amount of lithium. The final product, a 1 alpha ,3 beta -dihydorxy- DELTA 5-steroid, is useful in the synthesis of derivatives of cholecalciferol.

Inventors:
ANDORU FUERUSUTO
RUDOBUITSUHI RABURAA
BERUNAA MAIAA
Application Number:
JP14717679A
Publication Date:
May 30, 1980
Filing Date:
November 15, 1979
Export Citation:
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Assignee:
HOFFMANN LA ROCHE
International Classes:
C07J1/00; A61K31/59; A61P3/02; C07C67/00; C07C401/00; C07J7/00; C07J9/00; C07J17/00; C07J21/00; C07J71/00; C07J75/00; (IPC1-7): A61K31/59; C07C172/00; C07J1/00; C07J7/00; C07J9/00; C07J17/00; C07J71/00
Domestic Patent References:
JPS51110554A1976-09-30
JPS50160259A1975-12-25
JPS50160260A1975-12-25
JPS5165749A1976-06-07
JPS5077360A1975-06-24