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Title:
NOVEL MONOTHIOL MUCOLYTIC AGENTS
Document Type and Number:
Japanese Patent JP2021004256
Kind Code:
A
Abstract:
To provide a method of increasing the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties.SOLUTION: There are provided mucolytic agents represented by formula (la) to (ld) where the structural variables R1, R2, R5 and R6 are as defined herein. There are also provided a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (la) to (ld). One object of the present invention relates to a method of increasing the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. The method includes the step of contacting the mucus of a patient with abnormal or excessive mucus with a composition comprising a mucolytic compound containing a dithiol group to decrease mucus viscoelasticity through the reduction of mucin disulfide bonds.SELECTED DRAWING: Figure 1

Inventors:
MICHAEL ROSS JOHNSON
WILLIAM R THELIN
Application Number:
JP2020168248A
Publication Date:
January 14, 2021
Filing Date:
October 05, 2020
Export Citation:
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Assignee:
PARION SCIENCES INC
International Classes:
C07C327/06; A61K9/12; A61K31/047; A61K31/138; A61K31/341; A61K31/4188; A61K31/4965; A61K31/498; A61K33/14; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P1/10; A61P11/00; A61P11/02; A61P11/06; A61P11/10; A61P15/02; A61P17/16; A61P27/02; A61P27/14; A61P27/16; A61P31/04; A61P31/22; A61P39/06; A61P43/00; C07C323/16; C07D241/10; C07D241/18; C07D241/40; C07D307/56; C07D495/04
Domestic Patent References:
JP6826038B22021-02-03
JP2009535462A2009-10-01
Foreign References:
WO2012041451A12012-04-05
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito