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Title:
NOVEL ORGANIC SILICON COMPOUND, ITS PRODUCTION AND ANTITUMOR AGENT CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JPS6165890
Kind Code:
A
Abstract:

NEW MATERIAL:A compound of formula I (R is H, halogen, alkyl; R1WR3 are alkyl, alkoxy, phenyl which may be substituted, alkylcarbonyloxy, trialkylsilyloxy; R4 is H, alkyl, alkenyl; where in case of R1=R2=R3=CH3, m, n are not H simultaneously).

EXAMPLE: 1-[2-(3-Trimethylsilypropyl)thio]ethylcarbamoyl]-5-fluorouracil.

USE: Antitumor agent with low toxicity.

PREPARATION: The reaction of a compound of formula II such as 1- chloroformyl-5-fluorouracil with another compound of formula III such as 2-[(3- trimethylsilylpropyl)thio]ethylamine in equimolar amounts is carried out in a solvent such as pyridine in a atmosphere of argon, preferably at 0W10°C.


Inventors:
TOYOSHIMA SHIGERU
KURONO MASATSUNE
UNNO RYOICHI
KIMURA HIROMOTO
ITO KOICHI
ISHIHARA TOSHINOBU
YAMAMOTO AKIRA
Application Number:
JP18819784A
Publication Date:
April 04, 1986
Filing Date:
September 10, 1984
Export Citation:
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Assignee:
SANWA KAGAKU KENKYUSHO CO
SHINETSU CHEMICAL CO
International Classes:
A61K31/695; A61P35/00; C07F7/08; C07F7/10; C07F7/18; (IPC1-7): A61K31/695; C07F7/08; C07F7/18
Domestic Patent References:
JPS5663966A1981-05-30