NEW MATERIAL:The peptide compound of formulaI(R1 is n-octanoyl, stearoyl. n-docosanoyl, 2-acetoxypropionyl, etc.; R2 is H, methyl or benzyl; R3 is methoxy, carboxymethylamino, 1-methoxycarbonylethylamino, etc.; R4 is H, carboxy, methoxycarbonyl, carbazoyl, etc.; R5 is H, t-butoxycarbonyl, benzyloxycarbonyl, etc.; n is 0 or 1), or its salt.
EXAMPLE: The compound of formula II.
USE: Useful as a remedy for infectious diseases caused by pathogenic microorganisms, esp. Gram-negative bacteria, Gram-positive bacteria and fungi, and as a remedy for cancer of man and other animals.
PROCESS: The exemplified compound of formula II can be prepared, e.g. by the reaction for forming peptide bond, e.g. the reaction of the compound of formula III with the compound of formula IV. The compound of formulaIcan be prepared also by acylation reaction, methylation reaction, etc.
IGUCHI HIDEKO
KOUSAKA MASANOBU
AOKI HATSUO
IMANAKA HIROSHI
KITAURA YOSHIHIKO
NAKAGUCHI OSAMU
HENMI KEIJI
ARAYA MATSUHIKO
TAKENO SHIYUUICHI
OKADA TATSU
TANAKA HIROKAZU
HASHIMOTO SHINJI
| JPS5576850A | 1980-06-10 | |||
| JPS5585552A | 1980-06-27 | |||
| JPS5636440A | 1981-04-09 | |||
| JPS5645447A | 1981-04-25 |