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Title:
NOVEL TIN 2-NITROTHIOPHENOL COMPLEX COMPOUND, ITS PREPARATION AND PREPARATION OF THREO SUBSTITUTED- PROPIONIC ACID DERIVATIVE WITH THE SAME
Document Type and Number:
Japanese Patent JPS57193449
Kind Code:
A
Abstract:

PURPOSE: To obtain a threo substituted-propionic acid derivative which is a synthetic intermediate for anti Ca2+ coronary circulatory enchancers, etc. in high yield in a short time, by reacting a novel tin 2-nitrothiophenol complex compound with a specific glycidic ester.

CONSTITUTION: A compound of formula II is reacted with a compound of formula III (X is halogen or aliphatic acyloxy ; y is 4 or 2) to give a novel compound of formulaI(x is 0, 1 or 2). The reaction is carried out in a solvent, e.g. benzene, at -30W+60°C. The resultant compound is then reacted with a trans-3- (4-methoxyphenyl)glycidic ester of formula IV (R is ester residue) to give a threo substituted -propionic acid derivative of formula V. The reaction is carried out in a solvent, e.g. benzene, at 0W60°C usually within 10min. The resultant compound of formula V is useful as a synthetic interemediate for diltiazem hydrochloride.


Inventors:
INOUE HIROZUMI
HASHIYAMA TOMIKI
Application Number:
JP1981000078317
Publication Date:
November 27, 1982
Filing Date:
May 22, 1981
Export Citation:
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Assignee:
TANABE SEIYAKU CO
International Classes:
C07F7/22; B01J31/00; B01J31/22; C07B61/00; C07C67/00; C07C313/00; C07C319/14; C07C323/09; C07C323/56; (IPC1-7): B01J31/22; C07C148/00; C07C149/32



 
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