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Title:
O-置換ヒドロキシルアンモニウム塩の製造方法
Document Type and Number:
Japanese Patent JP4062369
Kind Code:
B2
Abstract:
An integrated process for the preparation of O-substituted hydroxyammonium salts of formula (I) without isolation of intermediates comprises: (a) reacting acetone with hydroxylammonium sulphate and sodium hydroxide solution to give acetone oxime of formula (II); (b) treating the obtained (II) solution with NaOH solution and completely eliminating water; (c) reacting the obtained suspension of acetone oxime sodium salt of formula (III) with an alkylating agent RY (IV) at 0.5-15 (preferably 1-4) bar and at up to 140 degrees C in presence of a phase transfer catalyst, to give an acetone oxime ether of formula (V); and (d) cleaving (V) with HX to give (I). Steps (a)-(c) are carried out in the same non-polar, aprotic solvent and step (d) is effected with concentrated acid. H2NOR.HX (I) Me2C=NOH (II) Me2C=NONa (III) Me2C=NOR (V) R = 1-6C alkyl or 2-6C alkenyl (both optionally substituted by halo); X = Cl or Br; and Y = nucleofugous group.

Inventors:
Michael, Kyle
Joseph, Val
Ulrich, Klein
Wolfgang, Ville
Application Number:
JP26654695A
Publication Date:
March 19, 2008
Filing Date:
October 16, 1995
Export Citation:
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Assignee:
BASF Aktiengesellschaft
International Classes:
C07C239/20; C07C249/04; C07C249/08; C07C249/12; C07C251/38; C07C251/40
Domestic Patent References:
JP60231645A
JP6199760A
Attorney, Agent or Firm:
Satoshi Eto



 
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