Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
O2-ARYLATED OR O2-GLYCOSYLATED 1-SUBSTITUTED DIAZEN-1-IUM-1,2-DIOLATES AND O2-SUBSTITUTED 1-[(2-CARBOXYLATO)PYRROLIDIN-1-YL]DIAZEN-1-IUM-1,2-DIOLATES
Document Type and Number:
Japanese Patent JP2009137965
Kind Code:
A
Abstract:

To provide new diazeniumdiolates, (wherein the N1 position is substituted by an inorganic or organic group and the O2-oxygen is bound to a substituted or unsubstituted aromatic group).

The invention provided O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates, (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in non-nucleophilic neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.


Inventors:
SAAVEDRA JOSEPH E
KEEFER LARRY K
BOGDAN CHRISTIAN
Application Number:
JP2008000311808
Publication Date:
June 25, 2009
Filing Date:
December 08, 2008
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
US GOVERNMENT (US)
International Classes:
C07D295/22; C07H5/06; A61K31/40; A61K31/44; A61K31/445; A61K31/495; A61K31/70; A61K31/7056; A61K31/706; A61K31/7072; A61P1/16; A61P7/00; A61P9/10; A61P11/00; A61P15/10; A61P29/00; A61P31/04; A61P31/12; A61P33/06; A61P35/04; A61P43/00; C07C291/08; C07D207/08; C07D211/26; C07D213/64; C07H1/00; C07H7/033; C07H19/073
Attorney, Agent or Firm:
Takashima Hajime