Title:
ナトリウム・グルコース共輸送体２阻害薬のＬ−プロリン化合物、およびＬ−プロリン化合物の一水和物および結晶
Document Type and Number:
Japanese Patent JP6761564
Kind Code:
B2
Abstract:
Provided are an L-proline compound of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline compound. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydrox ymethyl)-²-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and an A-type crystal thereof and a preparation method therefor. The obtained A-type crystal of the compound of formula (I) has good chemical stability and crystal stability, and a crystallization solvent used has low toxicity and low residue, so the A-type crystal can be better used in clinical treatment.
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Inventors:
Sun, Piao Yang
C, Guairi
Guo, Chang Shan
Ru, Yun
C, Yusia
Shen, Linzia
C, Guairi
Guo, Chang Shan
Ru, Yun
C, Yusia
Shen, Linzia
Application Number:
JP2017512686A
Publication Date:
September 30, 2020
Filing Date:
September 08, 2015
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO.,LTD.
International Classes:
C07H9/04; A61K31/401; A61K31/7048; A61P3/10
Domestic Patent References:
| JP2013533291A | ||||
| JP2012500842A | ||||
| JP2015522644A |
Foreign References:
| CN104031098A | ||||
| CN104017031A | ||||
| US20140303096 |
Attorney, Agent or Firm:
Xie Takamine
Tadayuki Motoyama
Tadayuki Motoyama