Title:
ONE-POT SYNTHESIS OF 2-OXAZOLIDINONE DERIVATIVE
Document Type and Number:
Japanese Patent JP3739678
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for synthesizing (S)-4-{[3-[2-(dimethylamino) ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone by an improved process.
SOLUTION: This method for synthesizing the 2-oxazolidinone derivative includes the following steps: (a) a step for forming a carbamate of the formula (III) from methyl 4-nitro-(L)-phenylalaninate hydrochloride; (b) another step for reducing the compound of the formula (III) to obtain a compound of the formula (IV); (c) a third step for reducing a methyl ester group in the compound of the formula (IV) to obtain a compound of the formula (V); (d) a fourth step for subjecting the compound of the formula (V) to ring closure to obtain a compound of the formula (VI); (e) a fifth step for forming a diazonium salt from the compound of the formula (VI) and then reducing the diazonium salt to obtain a compound of the formula (VII); and the other step for subjecting the compound of the formula (VII) to Fischer's reaction to obtain the (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone.
Inventors:
Radicanto Patel
Application Number:
JP2001228782A
Publication Date:
January 25, 2006
Filing Date:
August 02, 1996
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07C269/04; A61K31/00; A61K31/42; A61K31/421; A61K31/422; A61P25/00; A61P25/06; C07B61/00; C07C215/06; C07C219/06; C07C219/32; C07C269/06; C07C271/16; C07C271/20; C07C271/22; C07D263/20; C07D413/06; C07D209/14; C07C; C07D; (IPC1-7): C07C269/04; A61K31/421; A61P25/06; C07C269/06; C07C271/16; C07C271/22; C07D263/20; //C07M7:00
Domestic Patent References:
| JP5502679A | ||||
| JP5017427A | ||||
| JP3031249A | ||||
| JP5163233A | ||||
| JP3112969A |
Foreign References:
| WO1995017439A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
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