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Title:
OPTICALLY ACTIVE QUINOLINECARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH03218383
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula [R1 is lower alkyl; R2 is H, lower alkyl or (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl; R3 is H or lower alkyl].

EXAMPLE: S-(-)-6-fluoro-1-methyl-7-(4-methyl-1-piperazinyl)-4-oxo-4 H-[1,3]thiazeto[3,2-a]-3-carboxylic acid.

USE: An antibacterial agent against Gram-positive bacteria, Gram-negative bacteria, etc. It has low toxicity and is useful as a therapeutic agent for infectious diseases such as systemic infection, urinary infection and biliary infection.

PREPARATION: The exemplified compound can be produced e.g. by subjecting a solution of racemic 6-fluoro-1-methyl-7-(4-methyl-1-piperazinyl)-4-oxo-4 H-[1,3]thiazeto[3,2-a]-3-carboxylic acid to high performance liquid chromatography and purifying the eluted fraction.


Inventors:
KISE MASAHIRO
KITANO MASAHIKO
OZAKI MASAKUNI
KAZUNO KENJI
MATSUDA MASATO
Application Number:
JP1990000208364
Publication Date:
September 25, 1991
Filing Date:
August 06, 1990
Export Citation:
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Assignee:
NIPPON SHINYAKU CO LTD
International Classes:
C07D513/00; A61K31/495; A61P31/04; C07D513/04; (IPC1-7): A61K31/495; C07D513/00
Domestic Patent References:
JPH01230585A1989-09-14