Title:
【発明の名称】接合目的のためのタンパク質の光活性化
Document Type and Number:
Japanese Patent JPH08505119
Kind Code:
A
Abstract:
A protein containing one or more disulfide bonds, e.g., an antibody, is subjected to ultraviolet radiation to reduce one or more such bonds to reactive sulfhydryl groups; the resulting photoactivated protein is reacted with other chemical entity which is reactive with sulfhydryl, such as certain radiometals, chelating agents, drugs and toxins, so as to obtain a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
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Inventors:
Sykes, Thomas, Earl.
Wu, Thomas, Kay.
Queue Eye, Pay
No Jame, Antoine Ay.
Wu, Thomas, Kay.
Queue Eye, Pay
No Jame, Antoine Ay.
Application Number:
JP50348293A
Publication Date:
June 04, 1996
Filing Date:
July 06, 1993
Export Citation:
Assignee:
Bio Mira, Incorporated
International Classes:
A61K51/08; A61K51/10; C07K1/107; C07K1/13; C07K16/00; C12N13/00; G01N33/531; G01N33/534; G01N33/574; (IPC1-7): C07K1/13; C12N13/00; G01N33/531; G01N33/574
Attorney, Agent or Firm:
Kobayashi Koji (3 others)