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Title:
POLYPRENYL BASED COMPOUND AND PRODUCTION THEREOF AND PHARMACEUTICAL CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPS60123451
Kind Code:
A
Abstract:

NEW MATERIAL:A compound of formula I {A, B, Y and Z are together H or A and B and Y and Z together form single bond; n is an integer 1W3; X is formula II[R2 is formula III (R3 is H or lower alkyl; m is an integer 1W5), etc.; R1 is H, lower alkyl or halogen] or formula IV (K and L are h or K and L together form single bond), etc.}.

EXAMPLE: 2-Palmitoylamino-2-ethyl-1,3-propanediol.

USE: An antithrombotic agent having anti PAF action and antithrombin action.

PREPARATION: A polyprenylcarboxylic acid of formula V or a reactive derivative thereof is amidated with an amine in a solvent, e.g. dioxane or tetrahydrofurna, to afford the aimed compound of formula I .


Inventors:
YAMATSU ISAO
SUZUKI TAKESHI
ABE SHINYA
NAKAMOTO KOUJI
KAJIWARA SHIYOUJI
FUJIMORI TOORU
HARADA KOUKICHI
KITAMURA SHINICHI
Application Number:
JP1983000229819
Publication Date:
July 02, 1985
Filing Date:
December 07, 1983
Export Citation:
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Assignee:
EISAI CO LTD
International Classes:
C07D295/12; A61K31/40; A61K31/415; A61K31/44; A61K31/4406; A61K31/445; A61K31/535; A61K31/5375; A61P7/02; A61P43/00; C07C67/00; C07C209/00; C07C211/09; C07C233/36; C07C233/38; C07C233/68; C07C233/69; C07C233/78; C07D207/09; C07D211/56; C07D213/75; C07D233/60; (IPC1-7): A61K31/40; A61K31/415; A61K31/44; A61K31/445; A61K31/535; C07C87/14; C07C103/60; C07C103/64; C07C103/78; C07C103/82; C07D207/09; C07D211/56; C07D213/75; C07D233/60; C07D295/12
Domestic Patent References:
JP41006168A
JPS57192340A1982-11-26
JPS59101448A1984-06-12



 
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