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Title:
PREPARATION OF 2,4,5-TRIBROMOPYRROLE-3-CARBONITRILE
Document Type and Number:
Japanese Patent JP3544727
Kind Code:
B2
Abstract:

PURPOSE: To obtain at a high yield the subject compound useful as an insecticide, acaricide or molluscicide starting from a vinamidinium salt and a glycine ester in a process comprising three steps in each of which reaction is carried out using a specific base and a specific solvent.
CONSTITUTION: A vinamidinium salt of formula I [wherein R and R1-R3 are each a 1-4C alkyl, and, R and R1 or R2 and R3 each may together form a 5- or 6-membered ring when RR1 and R2R3 are each represented by -(CH2)4- or -(CH2)5-; and X- is an anion] is reacted with a glycine ester of formula II (wherein R4 is a 1-4C alkyl) in the presence of a first solvent and a first base to obtain a mixture containing a 4-cyanopyrrole-2-carboxylic acid ester of formula III. Subsequently the mixture is hydrolyzed with a second base in the presence of a second solvent to give a 4-cyanopyrrole-2-carboxylate, which is further reacted with a third base and a brominating agent in the presence of a third solvent to obtain 2,4,5-tribromopyrrole-3-carbonitrile.


Inventors:
Victor Mark Kamhi
Application Number:
JP33380094A
Publication Date:
July 21, 2004
Filing Date:
December 19, 1994
Export Citation:
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Assignee:
Wyeth Holdings Corporation
International Classes:
A01N43/36; C07B39/00; C07B41/08; C07D207/34; (IPC1-7): C07D207/34
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ishii Teiji



 
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