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Title:
PREPARATION OF 3-DEOXY-3-IODO-D-GLUCOFURANOSE DERIVATIVE
Document Type and Number:
Japanese Patent JPS56118095
Kind Code:
A
Abstract:

PURPOSE: To prepare the titled compound useful as a synthetic intermediate of an X-ray contrast medium, in high yield and purity, by reacting an allofuranose derivative with triphenyl phosphine and iodine in the presence of imidazole.

CONSTITUTION: An allofuranose derivative of formula I (R1 and R2 are lower alkyl) is made to react with triphenyl phosphine and iodine in a solvent such as toluene, benzene, etc., in the presence of imidazole, at 110W120°C for 2W3hr to obtain the objective compound of formula II in high safety. The preferably molar ratios of imidazole : triphenyl phosphine : iodine : the compound of formula I are 1.5:1.2:1.3:1.0W3:2:3:1. The process is industrially advantageous in view of safety, reaction time, purity, yield, etc.


Inventors:
HORIO YOSHIHIRO
AMANO MASARU
Application Number:
JP1980000019740
Publication Date:
September 16, 1981
Filing Date:
February 21, 1980
Export Citation:
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Assignee:
WAKAMOTO PHARMA CO LTD
International Classes:
C07H5/02; C07H9/04; (IPC1-7): C07H9/04
Domestic Patent References:
JPS4939263A1974-04-12
JPS52122314A1977-10-14



 
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