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Title:
プロバイオティクス菌株及びこれに由来する抗菌性ペプチド
Document Type and Number:
Japanese Patent JP2009538614
Kind Code:
A
Abstract:
A strain of Enterococcus mundtii has probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. An isolated nucleotide sequence codes for the antimicrobial peptide (peptide ST4SA). A process is also provided for the production of a peptide which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 10° C. and 45° C., until a recoverable quantity of the peptide is produced, and recovering the peptide. The isolated peptide may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.

Inventors:
Dicks, Leon Milneare Theodore
Todorov, Svetoslav Dimitrov
Noetze, Hendriette
Blink, Maleize
Application Number:
JP2009512739A
Publication Date:
November 12, 2009
Filing Date:
May 25, 2007
Export Citation:
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Assignee:
Shipramed Pro Research and Development (Proprietary) Limited
International Classes:
C12N15/09; A01N63/50; A23L1/30; A23L33/00; A61K35/744; A61K38/00; A61P31/04; C07K14/195; C12N1/15; C12N1/19; C12N1/20; C12N1/21; C12N5/10; C12P21/02; C12Q1/68; F41C27/06; C12R1/01
Domestic Patent References:
JP2003339377A2003-12-02
JP2002238465A2002-08-27
Foreign References:
WO2004005492A22004-01-15
Other References:
JPN6012026135; Int J Antimicrob Agents., 1999年, 第12巻, 293-299ページ
JPN6012026131; Appl Environ Microbiol., 2002年, 第68巻, 3830-3840ページ
JPN6012026132; Antimicrob Agents Chemother., 2004年, 第48巻, 2778-2781ページ
JPN6013036188; Feed Mix Special, 2000年, 28-30ページ
JPN6013036191; Int J Food Microbiol., 2006年1月, 第106巻, 1-24ページ
JPN6013036189; Int J Food Microbiol., 1999年, 第47巻, 1-24ページ
JPN6013036190; Anaerobe, 1997年, 第3巻, 73-78ページ
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Ikeda adult