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Title:
PRODRUG OF ASPARTYL PROTEASE INHIBITOR
Document Type and Number:
Japanese Patent JP2009102400
Kind Code:
A
Abstract:

To provide a prodrug of a class of sulfonamides which is an aspartyl protease inhibitor.

This invention relates to a new class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable water solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to a pharmaceutical composition comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to a method of treating mammals with these prodrugs and pharmaceutical compositions.


Inventors:
ROGER D TAN
MICHAEL R HALE
CHRISTOPHER T BAKER
ERIC STEVEN FARFAIN
ISTVAN COLDOLL
WISLOW MIIJIISUROU KAZMIERSKI
ANDREW SPALTENSTEIN
Application Number:
JP2009016033A
Publication Date:
May 14, 2009
Filing Date:
January 27, 2009
Export Citation:
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Assignee:
VERTEX PHARMACEUT INC
International Classes:
A61K31/265; A61K31/18; A61K31/215; A61K31/27; A61K31/34; A61K31/341; A61K31/4025; A61K31/4178; A61K31/443; A61K31/496; A61K31/66; A61K31/661; A61K31/664; A61K31/675; A61K31/685; A61K31/7048; A61K45/00; A61P31/12; A61P31/18; A61P43/00; C07C311/15; C07C311/18; C07C311/37; C07D277/30; C07D307/20; C07D405/12; C07D407/12; C07D417/12; C07F9/655; C07F9/6584; C07H15/04; C07H15/26
Attorney, Agent or Firm:
Shusaku Yamamoto
Takamura Yasumura
Morishita Natsuki