PURPOSE: To obtain the titled compound useful as an intermediate raw material especially for anti-inflammatory analgesic economically and readily, by using readily obtainable 2-nitro-3,4-dichloro-trifluoromethyl-toluene as a raw material and reacting the compound in the presence of a basic compound and a hydrogenating catalyst.
CONSTITUTION: 2-Nitro-3,4-dichloro-6-trifluoromethyl-toluene is used as a raw material and reacted in the presence of a basic substance such as sodium hydroxide, trimethylamine, etc., at about 0W150°C, preferably 80W120°C at 1W20kg/cm2, preferably 6W10kg/cm2 and the nitro group is hydrogenated and dechlorinated to give the aimed compound. Palladium supported on active carbon is especially preferable as the hydrogenating catalyst and the concentration of the catalyst is preferably about 1W5wt% based on the raw material compound. The raw material compound is obtained by nitrating 3,4-dichloro-6-trifluoromethyltoluene.
KAWAI TOSHIKAZU
OSHIO HIDEKI
